Dale W Laird Selected Research

Connexins

1/2022	Cellular mechanisms of connexin-based inherited diseases.
1/2021	Palmoplantar keratoderma with deafness phenotypic variability in a patient with an inherited GJB2 frameshift variant and novel missense variant.
1/2020	GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells.
1/2020	Involvement of the Gap Junction Protein, Connexin43, in the Formation and Function of Invadopodia in the Human U251 Glioblastoma Cell Line.
1/2019	The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss.
12/2018	Therapeutic strategies targeting connexins.
1/2018	Connexins and Disease.
1/2017	Disease-linked connexin26 S17F promotes volar skin abnormalities and mild wound healing defects in mice.
1/2017	Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss.
1/2017	Aberrant Cx43 Expression and Mislocalization in Metastatic Human Melanomas.

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Dale W Laird Research Topics

Disease

33	Oculodentodigital Dysplasia 01/2022 - 03/2005
19	Neoplasms (Cancer) 01/2022 - 08/2002
9	Breast Neoplasms (Breast Cancer) 01/2016 - 08/2002
6	Hearing Loss (Hearing Impairment) 01/2020 - 06/2015
6	Skin Diseases (Skin Disease) 01/2017 - 04/2004
4	Neoplasm Metastasis (Metastasis) 12/2021 - 08/2007
3	Deafness (Deaf Mutism) 01/2022 - 01/2017
3	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 01/2021 - 10/2006
3	Melanoma (Melanoma, Malignant) 01/2017 - 08/2012
3	Infections 06/2008 - 04/2005
2	Ichthyosis (Xeroderma) 01/2021 - 01/2017
2	Keratitis 01/2021 - 01/2017
2	Sensorineural Hearing Loss 01/2021 - 06/2016
2	Wounds and Injuries (Trauma) 12/2018 - 01/2017
2	Syndactyly (Polysyndactyly) 06/2017 - 10/2005
2	Dental Enamel Hypoplasia 06/2017 - 10/2005
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2016 - 06/2009
2	Hypoxia (Hypoxemia) 01/2015 - 09/2010
2	Carcinogenesis 01/2014 - 08/2007
2	Prostatic Neoplasms (Prostate Cancer) 08/2006 - 04/2005
1	Erythrokeratodermia Variabilis 01/2022
1	Blindness (Hysterical Blindness) 01/2022
1	Palmoplantar Keratoderma with Deafness 01/2021
1	Keratitis, Ichthyosis, and Deafness (KID) Syndrome 01/2021
1	Nonsyndromic Deafness 01/2021
1	Chronic Mucocutaneous Candidiasis 01/2021
1	Glioma (Gliomas) 01/2020
1	Glioblastoma (Glioblastoma Multiforme) 01/2020
1	Noise-Induced Hearing Loss (Acoustic Trauma) 01/2018
1	Intellectual Disability (Idiocy) 06/2016
1	Muscle Weakness 02/2016
1	Osteoarthritis 08/2015
1	Joint Diseases (Joint Disease) 08/2015
1	Sepsis (Septicemia) 01/2015
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 09/2014
1	Communicable Diseases (Infectious Diseases) 08/2014
1	Macular Degeneration (Age-Related Maculopathy) 04/2012
1	Glaucoma 06/2011
1	Parakeratosis 08/2010
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/2010
1	Disease Progression 08/2007
1	Congenital Abnormalities (Deformity) 03/2005
1	Experimental Liver Neoplasms 04/2002

Drug/Important Bio-Agent (IBA)

44	Connexin 43 (Connexin43)IBA 01/2022 - 08/2002
29	ConnexinsIBA 01/2022 - 08/2002
25	disodium salt olean-11,13(18)-diene-3,30-diol dihemiphthalateIBA 12/2020 - 07/2005
6	Proteins (Proteins, Gene)FDA Link 12/2021 - 07/2003
2	Connexin 26IBA 01/2019 - 10/2006
2	Green Fluorescent ProteinsIBA 01/2014 - 07/2003
2	Coloring Agents (Dyes)IBA 01/2014 - 10/2006
2	Small Interfering RNA (siRNA)IBA 02/2008 - 04/2005
1	Perilipin-1IBA 11/2019
1	Connexin 30IBA 01/2019
1	Keratin-6 (Keratin 6A)IBA 01/2017
1	Filaggrin ProteinsIBA 01/2017
1	Protein Isoforms (Isoforms)IBA 01/2017
1	Keratin-14 (Keratin 14)IBA 01/2017
1	Messenger RNA (mRNA)IBA 01/2016
1	Lactoglobulins (beta-Lactoglobulin)FDA Link 11/2015
1	anthraceneIBA 11/2015
1	Transforming Growth Factor beta (TGF-beta)IBA 06/2015
1	Retinoblastoma ProteinIBA 06/2015
1	LipopolysaccharidesIBA 01/2015
1	NucleotidesIBA 09/2014
1	Adenosine Triphosphate (ATP)IBA 09/2014
1	Purinergic Receptors (Receptors, Purine)IBA 09/2014
1	Pharmaceutical PreparationsIBA 09/2014
1	Glycoproteins (Glycoprotein)IBA 08/2014
1	VimentinIBA 08/2012
1	CateninsIBA 08/2012
1	Retinal Pigments (Pigments, Visual)IBA 04/2012
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2012
1	Eosine Yellowish-(YS) (Eosin)IBA 06/2011
1	Hematoxylin (Haematoxylon)IBA 06/2011
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2010
1	Oxidants (Oxidizing Agents)IBA 09/2010
1	AcetoneIBA 08/2010
1	Caveolin 1IBA 05/2010
1	RNA (Ribonucleic Acid)IBA 10/2007
1	Amino Acids FDA Link 10/2006
1	Histone Deacetylases (Histone Deacetylase)IBA 08/2006
1	Histones (Histone)IBA 08/2006
1	Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA 10/2005
1	IntegrinsIBA 04/2005
1	matrigelIBA 01/2005
1	CarbenoxoloneIBA 01/2005
1	NocodazoleIBA 04/2002
1	Cytochalasin BIBA 04/2002
1	Colchicine FDA LinkGeneric 04/2002

Therapy/Procedure

2	Therapeutics 12/2021 - 08/2015
1	Transjugular Intrahepatic Portasystemic Shunt 01/2021
1	Cochlear Implants (Cochlear Implant) 06/2016
1	Drug Therapy (Chemotherapy) 09/2014